The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo

Prion diseases are fatal neurodegenerative disorders affecting several mammalian species, characterized by the accumulation of the misfolded form of the prion protein, which is followed by the induction of endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR). G...

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Vydáno v:Sci Rep
Hlavní autoři: Park, Kyung-Won, Eun Kim, Gyoung, Morales, Rodrigo, Moda, Fabio, Moreno-Gonzalez, Ines, Concha-Marambio, Luis, Lee, Amy S., Hetz, Claudio, Soto, Claudio
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363067/
https://ncbi.nlm.nih.gov/pubmed/28333162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44723
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