Human Cytomegalovirus Specifically Controls the Levels of the Endoplasmic Reticulum Chaperone BiP/GRP78, Which Is Required for Virion Assembly

The endoplasmic reticulum (ER) chaperone BiP/GRP78 regulates ER function and the unfolded protein response (UPR). Human cytomegalovirus infection of human fibroblasts induces the UPR but modifies it to benefit viral replication. BiP/GRP78 protein levels are tightly regulated during infection, rising...

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Detalhes bibliográficos
Main Authors: Buchkovich, Nicholas J., Maguire, Tobi G., Yu, Yongjun, Paton, Adrienne W., Paton, James C., Alwine, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224369/
https://ncbi.nlm.nih.gov/pubmed/17942541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01881-07
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