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The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo

Prion diseases are fatal neurodegenerative disorders affecting several mammalian species, characterized by the accumulation of the misfolded form of the prion protein, which is followed by the induction of endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR). G...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Park, Kyung-Won, Eun Kim, Gyoung, Morales, Rodrigo, Moda, Fabio, Moreno-Gonzalez, Ines, Concha-Marambio, Luis, Lee, Amy S., Hetz, Claudio, Soto, Claudio
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363067/
https://ncbi.nlm.nih.gov/pubmed/28333162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44723
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