Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

Increased overall survival for patients with glioma brain tumours is associated with mutations in the metabolic regulator isocitrate dehydrogenase 1 (IDH1). Gliomas develop within a mechanically challenged microenvironment that is characterized by a dense extracellular matrix (ECM) that compromises...

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Détails bibliographiques
Publié dans:Nat Cell Biol
Auteurs principaux: Miroshnikova, Yekaterina A., Mouw, Janna K., Barnes, J. Matthew, Pickup, Michael W., Lakins, Johnathan N., Kim, Youngmi, Lobo, Khadjia, Persson, Anders I., Reis, Gerald F., McKnight, Tracy R., Holland, Eric C., Phillips, Joanna J., Weaver, Valerie M.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361403/
https://ncbi.nlm.nih.gov/pubmed/27820599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3429
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