Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

Heterozygous mutations in the gene encoding isocitrate dehydrogenase-1 (IDH1) occur in certain human brain tumors, but their mechanistic role in tumor development is unknown. We have shown that tumor-derived IDH1 mutations impair the enzyme’s affinity for its substrate and dominantly inhibit wild-ty...

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Autors principals: Zhao, Shimin, Lin, Yan, Xu, Wei, Jiang, Wenqing, Zha, Zhengyu, Wang, Pu, Yu, Wei, Li, Zhiqiang, Gong, Lingling, Peng, Yingjie, Ding, Jianping, Lei, Qunying, Guan, Kun-Liang, Xiong, Yue
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251015/
https://ncbi.nlm.nih.gov/pubmed/19359588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1170944
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