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Autophagy and Oxidative Stress in Gliomas with IDH1 Mutations
IDH1 mutations in gliomas associate with longer survival. Prooxidant and antiproliferative effects of IDH1 mutations and its D-2-hydroxyglutarate (2-HG) product have been described in vitro, but inconsistently observed. It is also unclear whether overexpression of mutant IDH1 in wild-type cells accu...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3946987/ https://ncbi.nlm.nih.gov/pubmed/24150401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1194-6 |
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