Autophagy and Oxidative Stress in Gliomas with IDH1 Mutations

IDH1 mutations in gliomas associate with longer survival. Prooxidant and antiproliferative effects of IDH1 mutations and its D-2-hydroxyglutarate (2-HG) product have been described in vitro, but inconsistently observed. It is also unclear whether overexpression of mutant IDH1 in wild-type cells accu...

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Bibliografiske detaljer
Main Authors: Gilbert, Misty R., Liu, Yinxing, Neltner, Janna, Pu, Hong, Morris, Andrew, Sunkara, Manjula, Pittman, Thomas, Kyprianou, Natasha, Horbinski, Craig
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946987/
https://ncbi.nlm.nih.gov/pubmed/24150401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1194-6
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