Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

Increased overall survival for patients with glioma brain tumours is associated with mutations in the metabolic regulator isocitrate dehydrogenase 1 (IDH1). Gliomas develop within a mechanically challenged microenvironment that is characterized by a dense extracellular matrix (ECM) that compromises...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Cell Biol
Prif Awduron: Miroshnikova, Yekaterina A., Mouw, Janna K., Barnes, J. Matthew, Pickup, Michael W., Lakins, Johnathan N., Kim, Youngmi, Lobo, Khadjia, Persson, Anders I., Reis, Gerald F., McKnight, Tracy R., Holland, Eric C., Phillips, Joanna J., Weaver, Valerie M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361403/
https://ncbi.nlm.nih.gov/pubmed/27820599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3429
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