Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

Increased overall survival for patients with glioma brain tumours is associated with mutations in the metabolic regulator isocitrate dehydrogenase 1 (IDH1). Gliomas develop within a mechanically challenged microenvironment that is characterized by a dense extracellular matrix (ECM) that compromises...

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Pubblicato in:Nat Cell Biol
Autori principali: Miroshnikova, Yekaterina A., Mouw, Janna K., Barnes, J. Matthew, Pickup, Michael W., Lakins, Johnathan N., Kim, Youngmi, Lobo, Khadjia, Persson, Anders I., Reis, Gerald F., McKnight, Tracy R., Holland, Eric C., Phillips, Joanna J., Weaver, Valerie M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361403/
https://ncbi.nlm.nih.gov/pubmed/27820599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3429
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