Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

Increased overall survival for patients with glioma brain tumours is associated with mutations in the metabolic regulator isocitrate dehydrogenase 1 (IDH1). Gliomas develop within a mechanically challenged microenvironment that is characterized by a dense extracellular matrix (ECM) that compromises...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nat Cell Biol
Hauptverfasser: Miroshnikova, Yekaterina A., Mouw, Janna K., Barnes, J. Matthew, Pickup, Michael W., Lakins, Johnathan N., Kim, Youngmi, Lobo, Khadjia, Persson, Anders I., Reis, Gerald F., McKnight, Tracy R., Holland, Eric C., Phillips, Joanna J., Weaver, Valerie M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361403/
https://ncbi.nlm.nih.gov/pubmed/27820599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3429
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge