NT-11 TARGETING INTERSTITIAL FLUID PRESSURE TO REDUCE TUMOR GROWTH AND INCREASE DRUG UPTAKE IN BRAIN TUMORS

High interstitial fluid pressure (IFP) represents a barrier for drug uptake in human GBM, the most common malignant primary brain tumor in adults. Increased IFP is due to leakiness of blood vessels and reduced drainage of fluid. This accumulation of fluid and high cell density compresses tumor tissu...

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Autores principales: Ilkhanizadeh, Shirin, Miroshnikova, Yekaterina, Frantz, Aaron, James, David, Berger, Mitchel, McKnight, Tracy, Weaver, Valerie, Weiss, William, Persson, Anders
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218420/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou265.11
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