STAT3 blockade inhibits a radiation-induced proneural-to-mesenchymal transition in glioma

Malignant progression is often associated with a mesenchymal phenotype and poor prognosis. To test whether radiotherapy promotes a mesenchymal transition, we irradiated proneural tumors arising in a genetically engineered mouse model for high-grade glioma. Cranial ionizing radiation induced a robust...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Lau, Jasmine, Ilkhanizadeh, Shirin, Wang, Susan, Miroshnikova, Yekaterina A., Salvatierra, Nicolas A., Wong, Robyn A., Schmidt, Christin, Weaver, Valerie M., Weiss, William A., Persson, Anders I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609277/
https://ncbi.nlm.nih.gov/pubmed/26282165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3331
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