EXTH-23. ANTISECRETORY FACTOR-MEDIATED LOWERING OF INTERSTITIAL FLUID PRESSURE PRODUCES ANTI-TUMOR ACTIVITY IN GLIOBLASTOMA

Glioblastoma (GBM) is among the most aggressive cancers. Although high interstitial fluid pressure presents a barrier to drug uptake, how mechanical stresses and osmotic changes impact tumor biology remains unclear. We show that inhibition of the sodium-potassium-chloride co-transporter 1 (NKCC1) hi...

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Pubblicato in:Neuro Oncol
Autori principali: Sabelstrom, Hanna, IIkhanizadeh, Shirin, Miroshnikova, Yekaterina A, Frantz, Aaron, Zhu, Wen, Idilli, Aurora, Quigley, David, Fenster, Trenten, Yuan, Edith, Saxena, Supna, Mouw, Janna K, Burdick, Jason A, Magnitsky, Sergey, Berger, Mitchel S, Arosio, Daniele, Sun, Dandan, Weaver, Valerie M, Weiss, William A, Persson, Anders I
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693048/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.317
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