EXTH-23. ANTISECRETORY FACTOR-MEDIATED LOWERING OF INTERSTITIAL FLUID PRESSURE PRODUCES ANTI-TUMOR ACTIVITY IN GLIOBLASTOMA

Glioblastoma (GBM) is among the most aggressive cancers. Although high interstitial fluid pressure presents a barrier to drug uptake, how mechanical stresses and osmotic changes impact tumor biology remains unclear. We show that inhibition of the sodium-potassium-chloride co-transporter 1 (NKCC1) hi...

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Published in:Neuro Oncol
Main Authors: Sabelstrom, Hanna, IIkhanizadeh, Shirin, Miroshnikova, Yekaterina A, Frantz, Aaron, Zhu, Wen, Idilli, Aurora, Quigley, David, Fenster, Trenten, Yuan, Edith, Saxena, Supna, Mouw, Janna K, Burdick, Jason A, Magnitsky, Sergey, Berger, Mitchel S, Arosio, Daniele, Sun, Dandan, Weaver, Valerie M, Weiss, William A, Persson, Anders I
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693048/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.317
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