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Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP25
Ubiquitin-specific protease (USP) 25, belonging to the USP family of deubiquitinases, harbors two tandem ubiquitin-interacting motifs (UIMs), a ~20-amino-acid α-helical stretch that binds to ubiquitin. However, the role of the UIMs in USP25 remains unclear. Here we show that the tandem UIM region bi...
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| Udgivet i: | Sci Rep |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5361193/ https://ncbi.nlm.nih.gov/pubmed/28327663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45037 |
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