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Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP25

Ubiquitin-specific protease (USP) 25, belonging to the USP family of deubiquitinases, harbors two tandem ubiquitin-interacting motifs (UIMs), a ~20-amino-acid α-helical stretch that binds to ubiquitin. However, the role of the UIMs in USP25 remains unclear. Here we show that the tandem UIM region bi...

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Foilsithe in:Sci Rep
Main Authors: Kawaguchi, Kohei, Uo, Kazune, Tanaka, Toshiaki, Komada, Masayuki
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361193/
https://ncbi.nlm.nih.gov/pubmed/28327663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45037
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