Ubiquitin-interacting Motifs Confer Full Catalytic Activity, but Not Ubiquitin Chain Substrate Specificity, to Deubiquitinating Enzyme USP37

Ubiquitin-specific proteases (USPs) consist of a family of deubiquitinating enzymes with more than 50 members in humans. Three of them, including USP37, contain ubiquitin-interacting motifs (UIMs), an ∼20-amino acid α-helical stretch that binds to ubiquitin. However, the roles of the UIMs in these U...

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Hlavní autoři: Tanno, Hidetaka, Shigematsu, Takeshi, Nishikawa, Shuhei, Hayakawa, Akira, Denda, Kimitoshi, Tanaka, Toshiaki, Komada, Masayuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900984/
https://ncbi.nlm.nih.gov/pubmed/24324262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.528372
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