Selective binding of AIRAPL tandem UIMs to Lys48- linked tri-ubiquitin chains

Lys48-linked ubiquitin chains act as the main targeting signals for protein degradation by the proteasome. Here we report selective binding of AIRAPL, a protein that associates with the proteasome upon exposure to arsenite, to Lys48-linked tri-ubiquitin chains. AIRAPL comprises two ubiquitin-interac...

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Gepubliceerd in:Structure
Hoofdauteurs: Rahighi, Simin, Braunstein, Ilana, Ternette, Nicola, Kessler, Benedikt, Kawasaki, Masato, Kato, Ryuichi, Matsui, Tsutomu, Weiss, Thomas M., Stanhill, Ariel, Wakatsuki, Soichi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775417/
https://ncbi.nlm.nih.gov/pubmed/26876100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.12.017
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