Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe

One of the most abundant G-protein coupled receptors (GPCRs) in brain, the cannabinoid 1 receptor (CB1R), is a tractable therapeutic target for treating diverse psychobehavioral and somatic disorders. Adverse on-target effects associated with small-molecule CB1R orthosteric agonists and inverse agon...

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Bibliografiset tiedot
Julkaisussa:ACS Chem Neurosci
Päätekijät: Laprairie, Robert B., Kulkarni, Abhijit R., Kulkarni, Pushkar M., Hurst, Dow P., Lynch, Diane, Reggio, Patricia H., Janero, David R., Pertwee, Roger G., Stevenson, Lesley A., Kelly, Melanie E. M., Denovan-Wrigh, Eileen M., Thakur, Ganesh A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358098/
https://ncbi.nlm.nih.gov/pubmed/27046127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00041
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