Identification of CB1 Receptor Allosteric Sites Using Force-Biased MMC Simulated Annealing and Validation by Structure–Activity Relationship Studies

[Image: see text] Positive allosteric modulation of the cannabinoid 1 receptor (CB1R) has demonstrated distinct therapeutic advantages that address several limitations associated with orthosteric agonism and has opened a promising therapeutic avenue for further drug development. To advance the devel...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Hurst, Dow P., Garai, Sumanta, Kulkarni, Pushkar M., Schaffer, Peter C., Reggio, Patricia H., Thakur, Ganesh A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691559/
https://ncbi.nlm.nih.gov/pubmed/31413808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00256
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