Positive allosteric modulation of CB1 suppresses pathological pain without producing tolerance or dependence

BACKGROUND: Activation of cannabinoid CB1 receptors suppresses pathological pain but also produces unwanted central side effects. We hypothesized that a positive allosteric modulator (PAM) of CB1 signaling would suppress inflammatory and neuropathic pain without producing cannabimimetic effects or p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biol Psychiatry
Prif Awduron: Slivicki, Richard A., Xu, Zhili, Kulkarni, Pushkar M., Pertwee, Roger G., Mackie, Ken, Thakur, Ganesh A., Hohmann, Andrea G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758437/
https://ncbi.nlm.nih.gov/pubmed/28823711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.06.032
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