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The In Vivo Effects of the CB(1)-Positive Allosteric Modulator GAT229 on Intraocular Pressure in Ocular Normotensive and Hypertensive Mice
Purpose: Orthosteric cannabinoid receptor 1 (CB(1)) activation leads to decreases in intraocular pressure (IOP). However, use of orthosteric CB(1) agonists chronically has several disadvantages, limiting their usefulness as clinically relevant drugs. Allosteric modulators interact with topographical...
Enregistré dans:
| Publié dans: | J Ocul Pharmacol Ther |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Mary Ann Liebert, Inc.
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5649393/ https://ncbi.nlm.nih.gov/pubmed/28719234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jop.2017.0037 |
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