Enantiomer-specific positive allosteric modulation of CB(1) signaling in autaptic hippocampal neurons

The cannabinoid signaling system is found throughout the CNS and its involvement in several pathological processes makes it an attractive therapeutic target. Because orthosteric CB1 cannabinoid receptor ligands have undesirable adverse effects there has been great interest in the development of allo...

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Bibliografiske detaljer
Udgivet i:Pharmacol Res
Main Authors: Mitjavila, Jose, Yin, Danielle, Kulkarni, Pushkar M., Zanato, Chiara, Thakur, Ganesh A., Ross, Ruth, Greig, Iain, Mackie, Ken, Straiker, Alex
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828971/
https://ncbi.nlm.nih.gov/pubmed/29158048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2017.11.019
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