Enantiomer-specific positive allosteric modulation of CB(1) signaling in autaptic hippocampal neurons

The cannabinoid signaling system is found throughout the CNS and its involvement in several pathological processes makes it an attractive therapeutic target. Because orthosteric CB1 cannabinoid receptor ligands have undesirable adverse effects there has been great interest in the development of allo...

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Pubblicato in:Pharmacol Res
Autori principali: Mitjavila, Jose, Yin, Danielle, Kulkarni, Pushkar M., Zanato, Chiara, Thakur, Ganesh A., Ross, Ruth, Greig, Iain, Mackie, Ken, Straiker, Alex
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828971/
https://ncbi.nlm.nih.gov/pubmed/29158048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2017.11.019
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