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Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons

Fragile X Syndrome (FXS) is a heritable form of mental retardation caused by a non-coding trinucleotide expansion of the FMR1 gene leading to loss of expression of this RNA binding protein. Mutations in this gene are strongly linked to enhanced Group I metabotropic glutamate receptor (mGluR) signali...

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Detalhes bibliográficos
Main Authors: Straiker, Alex, Min, Kyung-Tai, Mackie, Ken
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702050/
https://ncbi.nlm.nih.gov/pubmed/23578490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.04.002
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