Chronic cannabinoid CB(2) activation reverses paclitaxel neuropathy without tolerance or CB(1)-dependent withdrawal

BACKGROUND: Mixed cannabinoid CB(1)/CB(2) agonists such as Δ(9)-tetrahydrocannabinol (Δ(9)-THC) can produce tolerance, physical withdrawal, and unwanted CB(1)-mediated central nervous system side effects. Whether repeated systemic administration of a CB(2)-preferring agonist engages CB(1) receptors...

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Hlavní autoři: Deng, Liting, Guindon, Josée, Cornett, Benjamin L., Makriyannis, Alexandros, Mackie, Ken, Hohmann, Andrea G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209205/
https://ncbi.nlm.nih.gov/pubmed/24853387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2014.04.009
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