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CB(1) Knockout Mice Unveil Sustained CB(2)-Mediated Antiallodynic Effects of the Mixed CB(1)/CB(2) Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain

Cannabinoids suppress neuropathic pain through activation of cannabinoid CB(1) and/or CB(2) receptors; however, unwanted CB(1)-mediated cannabimimetic effects limit clinical use. We asked whether CP55,940 [(−)-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-4-(3-hydroxypropyl)cyclohexanol], a potent cann...

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Bibliografiske detaljer
Udgivet i:Mol Pharmacol
Main Authors: Deng, Liting, Cornett, Benjamin L., Mackie, Ken, Hohmann, Andrea G.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468646/
https://ncbi.nlm.nih.gov/pubmed/25904556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.098483
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