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CB(1) Knockout Mice Unveil Sustained CB(2)-Mediated Antiallodynic Effects of the Mixed CB(1)/CB(2) Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain
Cannabinoids suppress neuropathic pain through activation of cannabinoid CB(1) and/or CB(2) receptors; however, unwanted CB(1)-mediated cannabimimetic effects limit clinical use. We asked whether CP55,940 [(−)-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-4-(3-hydroxypropyl)cyclohexanol], a potent cann...
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| Publicado en: | Mol Pharmacol |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4468646/ https://ncbi.nlm.nih.gov/pubmed/25904556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.098483 |
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