The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB(2) receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy

BACKGROUND: Chemotherapeutic agents produce dose-limiting peripheral neuropathy through mechanisms that remain poorly understood. We previously showed that AM1710, a cannabilactone CB(2) agonist, produces antinociception without producing central nervous system (CNS)-associated side effects. The pre...

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Bibliografske podrobnosti
Main Authors: Deng, Liting, Guindon, Josée, Vemuri, V Kiran, Thakur, Ganesh A, White, Fletcher A, Makriyannis, Alexandros, Hohmann, Andrea G
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502129/
https://ncbi.nlm.nih.gov/pubmed/22998838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-71
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