Converting adult pancreatic islet α-cells into β-cells by targeting both Dnmt1 and Arx

Insulin-producing pancreatic β-cells in mice can slowly regenerate from glucagon-producing α-cells in settings like β-cell loss, but the basis of this conversion is unknown. Moreover it remains unclear if this intra-islet cell conversion is relevant to diseases like type 1 diabetes (T1D). We show th...

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Gepubliceerd in:Cell Metab
Hoofdauteurs: Chakravarthy, Harini, Gu, Xueying, Enge, Martin, Dai, Xiaoqing, Wang, Yong, Damond, Nicolas, Downie, Carolina, Liu, Kathy, Wang, Jing, Xing, Yuan, Chera, Simona, Thorel, Fabrizio, Quake, Stephen, Oberholzer, Jose, MacDonald, Patrick E., Herrera, Pedro L., Kim, Seung K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358097/
https://ncbi.nlm.nih.gov/pubmed/28215845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.01.009
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