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Converting adult pancreatic islet α-cells into β-cells by targeting both Dnmt1 and Arx
Insulin-producing pancreatic β-cells in mice can slowly regenerate from glucagon-producing α-cells in settings like β-cell loss, but the basis of this conversion is unknown. Moreover it remains unclear if this intra-islet cell conversion is relevant to diseases like type 1 diabetes (T1D). We show th...
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| Publicat a: | Cell Metab |
|---|---|
| Autors principals: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5358097/ https://ncbi.nlm.nih.gov/pubmed/28215845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.01.009 |
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