Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

OBJECTIVE: To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis. RESEARCH DESIGN AND METHODS: We generated a new transgenic model allowing near-total α-cell re...

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Detalhes bibliográficos
Main Authors: Thorel, Fabrizio, Damond, Nicolas, Chera, Simona, Wiederkehr, Andreas, Thorens, Bernard, Meda, Paolo, Wollheim, Claes B., Herrera, Pedro L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198058/
https://ncbi.nlm.nih.gov/pubmed/21926270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0876
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