In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice

OBJECTIVE: To establish the role of the transcription factor Pax4 in pancreatic islet expansion and survival in response to physiological stress and its impact on glucose metabolism, we generated transgenic mice conditionally and selectively overexpressing Pax4 or a diabetes-linked mutant variant (P...

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Detalhes bibliográficos
Main Authors: He, Kai Hui Hu, Lorenzo, Petra I., Brun, Thierry, Jimenez Moreno, Carmen M., Aeberhard, Deborah, Ortega, Jorge Vallejo, Cornu, Marion, Thorel, Fabrizio, Gjinovci, Asllan, Thorens, Bernard, Herrera, Pedro L., Meda, Paolo, Wollheim, Claes B., Gauthier, Benoit R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114382/
https://ncbi.nlm.nih.gov/pubmed/21521872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1102
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