PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet

PAX4 is a key regulator of pancreatic islet development whilst in adult acute overexpression protects β-cells against stress-induced apoptosis and stimulates proliferation. Nonetheless, sustained PAX4 expression promotes β-cell dedifferentiation and hyperglycemia, mimicking β-cell failure in diabeti...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lorenzo, Petra I., Fuente-Martín, Esther, Brun, Thierry, Cobo-Vuilleumier, Nadia, Jimenez-Moreno, Carmen María, G. Herrera Gomez, Irene, López Noriega, Livia, Mellado-Gil, José Manuel, Martin-Montalvo, Alejandro, Soria, Bernat, Gauthier, Benoit R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622080/
https://ncbi.nlm.nih.gov/pubmed/26503027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15672
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