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The diabetes-linked transcription factor PAX4 promotes β-cell proliferation and survival in rat and human islets
The mechanism by which the β-cell transcription factor Pax4 influences cell function/mass was studied in rat and human islets of Langerhans. Pax4 transcripts were detected in adult rat islets, and levels were induced by the mitogens activin A and betacellulin. Wortmannin suppressed betacellulin-indu...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172618/ https://ncbi.nlm.nih.gov/pubmed/15596543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200405148 |
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