Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells

Myeloid-derived suppressor cells (MDSCs) are immune suppressive cells that are hallmarks of human cancer. MDSCs inhibit cytotoxic T lymphocytes (CTLs) and NK cell functions to promote tumor immune escape and progression, and therefore are considered key targets in cancer immunotherapy. Recent studie...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liu, Feiyan, Li, Xia, Lu, Chunwan, Bai, Aiping, Bielawski, Jacek, Bielawska, Alicja, Marshall, Brendan, Schoenlein, Patricia V., Lebedyeva, Iryna O., Liu, Kebin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356634/
https://ncbi.nlm.nih.gov/pubmed/27880732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13438
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