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C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing

Because of the failure of single modality approaches, combination therapy for cancer treatment is a promising alternative. Sphingolipid analogs, with or without anticancer drugs, can improve tumor response. C16-pyridinium ceramide analog LCL30, was used in combination with photodynamic therapy (PDT...

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Detalhes bibliográficos
Main Authors: Duska Separovic, Ziad H. Saad, Ethan A. Edwin, Jacek Bielawski, Jason S. Pierce, Eric Van Buren, Alicja Bielawska
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Limited 2011-01-01
Colecção:Journal of Lipids
Acesso em linha:http://dx.doi.org/10.1155/2011/713867
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