C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing

Because of the failure of single modality approaches, combination therapy for cancer treatment is a promising alternative. Sphingolipid analogs, with or without anticancer drugs, can improve tumor response. C16-pyridinium ceramide analog LCL30, was used in combination with photodynamic therapy (PDT)...

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Bibliographic Details
Main Authors: Separovic, Duska, Saad, Ziad H., Edwin, Ethan A., Bielawski, Jacek, Pierce, Jason S., Buren, Eric Van, Bielawska, Alicja
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066794/
https://ncbi.nlm.nih.gov/pubmed/21490809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/713867
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