Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization

Two anticancer agents, LCL85 and photodynamic therapy (PDT) were combined to test whether the combination PDT/LCL85 evokes changes in the sphingolipid (SL) profile and promotes cell death. Treatment of SCCVII mouse squamous carcinoma cells using the silicone phthalocyanine Pc 4 for PDT induced incre...

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Detalhes bibliográficos
Main Authors: Separovic, Duska, Joseph, Nicholas, Breen, Paul, Bielawski, Jacek, Pierce, Jason S., Van Buren, Eric, Bhatti, Gaurav, Saad, Ziad H., Bai, Aiping, Bielawska, Alicja
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123537/
https://ncbi.nlm.nih.gov/pubmed/21545791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.04.091
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