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Dose Dependent Actions of LCL521 on Acid Ceramidase and Key Sphingolipid Metabolites.
The function of acid ceramidase (ACDase), whose congenital deficiency leads to Farber disease, has been recognized to be vital to tumor cell biology, and inhibition of its activity may be beneficial in cancer therapy. Therefore, manipulation of the activity of this enzyme may have significant effect...
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| Опубликовано в: : | Bioorg Med Chem |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6323005/ https://ncbi.nlm.nih.gov/pubmed/30448190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.11.012 |
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