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Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase

Acid ceramidase, which catalyzes ceramide hydrolysis to sphingosine and free fatty acid mainly in the lysosome, is being recognized as a potential therapeutic target for cancer. B13 is an effective and selective acid ceramidase inhibitor in vitro, but not as effective in cells due to poor access to...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS One
Main Authors: Bai, Aiping, Mao, Cungui, Jenkins, Russell W., Szulc, Zdzislaw M., Bielawska, Alicja, Hannun, Yusuf A.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470663/
https://ncbi.nlm.nih.gov/pubmed/28614356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177805
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