Targeting (cellular) lysosomal acid ceramidase by B13: Design, synthesis and evaluation of novel DMG-B13 ester prodrugs

Acid ceramidase (ACDase) is being recognized as a therapeutic target for cancer. B13 represents a moderate inhibitor of ACDase. The present study concentrates on the lysosomal targeting of B13 via its N, N-dimethylglycine (DMG) esters (DMG-B13 prodrugs). Novel analogs, the isomeric mono-DMG-B13, LCL...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Bai, Aiping, Szulc, Zdzislaw, M., Bielawski, Jacek, Pierce, Jason S., Rembisa, Barbara, Terzieva, Silva, Mao, Cungui, Xu, Ruijuan, Wu, Bill, Clarke, Christopher J., Newcomb, Benjamin, Liu, Xiang, Norris, James, Hannun, Yusuf A., Bielawska, Alicja
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443482/
https://ncbi.nlm.nih.gov/pubmed/25456083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.10.025
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