Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression

BACKGROUND: Ceramide is a bioeffector that mediates various cellular processes, including apoptosis. However, the mechanism underlying ceramide function in apoptosis is apparently cell type-dependent and is not well-understood. We aimed at identifying molecular targets of ceramide in metastatic huma...

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Hauptverfasser: Paschall, Amy V, Zimmerman, Mary A, Torres, Christina M, Yang, Dafeng, Chen, May R, Li, Xia, Bieberich, Erhard, Bai, Aiping, Bielawski, Jacek, Bielawska, Alicja, Liu, Kebin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898374/
https://ncbi.nlm.nih.gov/pubmed/24422988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-24
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