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Non-peptidic and Potent Small-Molecule Inhibitors of cIAP-1/2 and XIAP Proteins

A series of compounds were designed and synthesized as antagonists of cIAP-1/2 and XIAP based upon our previously identified lead compound SM-122 (1). The most potent of these (7) binds to XIAP, cIAP-1 and cIAP-2 proteins with K(i) values of 36, <1 and <1.9 nM, respectively. Consistent with it...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sun, Haiying, Lu, Jianfeng, Liu, Liu, Yi, Han, Qiu, Su, Yang, Chao-Yie, Deschamps, Jeffrey R., Wang, Shaomeng
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936695/
https://ncbi.nlm.nih.gov/pubmed/20684551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100487z
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