A carregar...
Non-peptidic and Potent Small-Molecule Inhibitors of cIAP-1/2 and XIAP Proteins
A series of compounds were designed and synthesized as antagonists of cIAP-1/2 and XIAP based upon our previously identified lead compound SM-122 (1). The most potent of these (7) binds to XIAP, cIAP-1 and cIAP-2 proteins with K(i) values of 36, <1 and <1.9 nM, respectively. Consistent with it...
Na minha lista:
| Main Authors: | , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2936695/ https://ncbi.nlm.nih.gov/pubmed/20684551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100487z |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|