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Non-peptidic and Potent Small-Molecule Inhibitors of cIAP-1/2 and XIAP Proteins
A series of compounds were designed and synthesized as antagonists of cIAP-1/2 and XIAP based upon our previously identified lead compound SM-122 (1). The most potent of these (7) binds to XIAP, cIAP-1 and cIAP-2 proteins with K(i) values of 36, <1 and <1.9 nM, respectively. Consistent with it...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2936695/ https://ncbi.nlm.nih.gov/pubmed/20684551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100487z |
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