Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells

[Image: see text] Cellular inhibitor of apoptosis protein 1 and 2 (cIAP1/2) and X-linked inhibitor of apoptosis protein (XIAP) are key apoptosis regulators and promising new cancer therapeutic targets. This study describes a set of non-peptide, small-molecule Smac (second mitochondria-derived activa...

Full description

Saved in:
Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Sun, Haiying, Lu, Jianfeng, Liu, Liu, Yang, Chao-Yie, Wang, Shaomeng
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324444/
https://ncbi.nlm.nih.gov/pubmed/24521431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400889a
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items