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Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells
[Image: see text] Cellular inhibitor of apoptosis protein 1 and 2 (cIAP1/2) and X-linked inhibitor of apoptosis protein (XIAP) are key apoptosis regulators and promising new cancer therapeutic targets. This study describes a set of non-peptide, small-molecule Smac (second mitochondria-derived activa...
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| Vydáno v: | ACS Chem Biol |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American
Chemical
Society
2014
|
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4324444/ https://ncbi.nlm.nih.gov/pubmed/24521431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400889a |
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