Synthesis, NMR characterization and divergent biological actions of 2′-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells

A straightforward method for the simultaneous preparation of (2S, 3R, 2′R)- and (2S, 3R, 2′S)-2′-hydroxy-ceramides (2′-OHCer) from (2S, 3R)-sphingosine acetonide precursors and racemic mixtures of 2-hydroxy fatty acids (2-OHFAs) is described. The obtained 2′-OH-C4-, -C6-, -C12-, -C16-Cer and 2′-OH-C...

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Main Authors: Szulc, Zdzislaw M., Bai, Aiping, Bielawski, Jacek, Mayroo, Nalini, Miller, Doreen E., Gracz, Hanna, Hannun, Yusuf A., Bielawska, Alicja
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956829/
https://ncbi.nlm.nih.gov/pubmed/20851613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.08.050
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