Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity

Conversion of fibroblasts into functional cardiomyocytes represents a potential means of restoring cardiac function after myocardial infarction, but so far this process remains inefficient and little is known about its molecular mechanisms. Here we show that DAPT, a classical Notch inhibitor, enhanc...

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Bibliografiska uppgifter
I publikationen:Stem Cell Reports
Huvudupphovsmän: Abad, Maria, Hashimoto, Hisayuki, Zhou, Huanyu, Morales, Maria Gabriela, Chen, Beibei, Bassel-Duby, Rhonda, Olson, Eric N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355682/
https://ncbi.nlm.nih.gov/pubmed/28262548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.01.025
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