Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors

Various combinations of cardiogenic transcription factors, including Gata4 (G), Hand2 (H), Mef2c (M) and Tbx5 (T), can reprogram fibroblasts into induced cardiac-like myocytes (iCLMs) in vitro and in vivo. Given that optimal cardiac function relies on distinct yet functionally interconnected atrial,...

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Detalles Bibliográficos
Publicado en:Development
Main Authors: Nam, Young-Jae, Lubczyk, Christina, Bhakta, Minoti, Zang, Tong, Fernandez-Perez, Antonio, McAnally, John, Bassel-Duby, Rhonda, Olson, Eric N., Munshi, Nikhil V.
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists 2014
Assuntos:
Stem Cells and Regeneration
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302916/
https://ncbi.nlm.nih.gov/pubmed/25344074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.114025
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