Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors

Various combinations of cardiogenic transcription factors, including Gata4 (G), Hand2 (H), Mef2c (M) and Tbx5 (T), can reprogram fibroblasts into induced cardiac-like myocytes (iCLMs) in vitro and in vivo. Given that optimal cardiac function relies on distinct yet functionally interconnected atrial,...

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Vydáno v:Development
Hlavní autoři: Nam, Young-Jae, Lubczyk, Christina, Bhakta, Minoti, Zang, Tong, Fernandez-Perez, Antonio, McAnally, John, Bassel-Duby, Rhonda, Olson, Eric N., Munshi, Nikhil V.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2014
Témata:
Stem Cells and Regeneration
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302916/
https://ncbi.nlm.nih.gov/pubmed/25344074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.114025
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