Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors

Various combinations of cardiogenic transcription factors, including Gata4 (G), Hand2 (H), Mef2c (M) and Tbx5 (T), can reprogram fibroblasts into induced cardiac-like myocytes (iCLMs) in vitro and in vivo. Given that optimal cardiac function relies on distinct yet functionally interconnected atrial,...

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Publicado en:Development
Autores principales: Nam, Young-Jae, Lubczyk, Christina, Bhakta, Minoti, Zang, Tong, Fernandez-Perez, Antonio, McAnally, John, Bassel-Duby, Rhonda, Olson, Eric N., Munshi, Nikhil V.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2014
Materias:
Stem Cells and Regeneration
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302916/
https://ncbi.nlm.nih.gov/pubmed/25344074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.114025
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