Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors

Various combinations of cardiogenic transcription factors, including Gata4 (G), Hand2 (H), Mef2c (M) and Tbx5 (T), can reprogram fibroblasts into induced cardiac-like myocytes (iCLMs) in vitro and in vivo. Given that optimal cardiac function relies on distinct yet functionally interconnected atrial,...

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Bibliografske podrobnosti
izdano v:Development
Main Authors: Nam, Young-Jae, Lubczyk, Christina, Bhakta, Minoti, Zang, Tong, Fernandez-Perez, Antonio, McAnally, John, Bassel-Duby, Rhonda, Olson, Eric N., Munshi, Nikhil V.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2014
Teme:
Stem Cells and Regeneration
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302916/
https://ncbi.nlm.nih.gov/pubmed/25344074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.114025
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