The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming

Direct cardiac reprogramming of fibroblasts to cardiomyocytes presents an attractive therapeutic strategy to restore cardiac function following injury. Cardiac reprogramming was initially achieved through overexpression of the transcription factors Gata4, Mef2c and Tbx5; later, Hand2 and Akt1 were f...

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Pubblicato in:Nat Cell Biol
Autori principali: Garry, Glynnis A., Bezprozvannaya, Svetlana, Chen, Kenian, Zhou, Huanyu, Hashimoto, Hisayuki, Morales, Maria Gabriela, Liu, Ning, Bassel-Duby, Rhonda, Olson, Eric N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8243412/
https://ncbi.nlm.nih.gov/pubmed/33941892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-021-00668-z
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